woman with braided hair looking to the side

Taking EBGLYSS

Actor portrayals.

Actor portrayals.

Taking EBGLYSS

See how to use EBGLYSS

[00:00-00:01]: [EBGLYSS wave animates on screen; EBGLYSS waves whoosh through frame]

[00:02-00:04]: [EBGLYSS logo animates on screen]

[00:05-00:07]: [Woman is working on her computer]
[Legal Super] Actor portrayal.

[00:08-00:14]: [EBGLYSS logo and dosing information build and remain on the screen; title card on screen]
[VO] This video will show you how to properly administer EBGLYSS using the Prefilled Pen.
[Caption] Using your EBGLYSS Prefilled Pen (250 mg/2 mL)
[Legal Super] Please see safety information throughout this video and the Indication and Safety Summary at the end of the video.

[00:15-00:16]: [EBGLYSS logo and dosing information remain on the screen; title card on screen]
[VO] Please see safety information throughout this video…
[Caption] Using your EBGLYSS Prefilled Pen (250 mg/2 mL)
[Legal Super] Please see safety information throughout this video and the Indication and Safety Summary at the end of the video.

[00:17-00:19]: [EBGLYSS logo and dosing information remain on the screen; title card on screen]
[VO] …and the Indication and Safety Summary at the end of the video.
[Caption] Using your EBGLYSS Prefilled Pen (250 mg/2 mL)
[Legal Super] Please see safety information throughout this video and the Indication and Safety Summary at the end of the video.

[00:20-00:23]: [EBGLYSS logo and dosing information remain on the screen]
[VO] It is important to read the full Instructions for Use before injecting.
[Caption] Using your EBGLYSS Prefilled Pen (250 mg/2 mL)
[Legal Super] Read the full Instructions for Use before injecting.

[00:24-00:29]: [EBGLYSS logo and dosing information remain on the screen; injection chapters with icons build on screen; icons and corresponding copy animate on screen]
[VO] Do not use until you have been shown how to inject EBGLYSS by your healthcare provider.
[Caption]:
[Checkmark Icon] Get ready
[Injection Icon] Inject
[Star Icon] Finish
[Legal Super] Do not use until you have been shown how to inject EBGLYSS by your healthcare provider. If you are a parent or caregiver giving an injection to someone else, be sure to read and understand the full Instructions for Use before injecting.

[00:30-00:32]: [EBGLYSS logo, dosing information, and injection chapters remain on screen; icons and corresponding copy animate on screen]
[VO] If you are a parent or caregiver giving an injection to someone else...
[Caption]:
[Checkmark Icon] Get ready
[Injection Icon] Inject
[Star Icon] Finish
[Legal Super] Do not use until you have been shown how to inject EBGLYSS by your healthcare provider. If you are a parent or caregiver giving an injection to someone else, be sure to read and understand the full Instructions for Use before injecting.

[00:33-00:38]: [EBGLYSS logo, dosing information, and injection chapters remain on screen; icons and corresponding copy animate on screen]
[VO] …be sure to read and understand the full Instructions for Use before injecting.
[Caption]:
[Checkmark Icon] Get ready
[Injection Icon] Inject
[Star Icon] Finish
[Legal Super] Do not use until you have been shown how to inject EBGLYSS by your healthcare provider. If you are a parent or caregiver giving an injection to someone else, be sure to read and understand the full Instructions for Use before injecting.

[00:39-00:45]: [Woman is working on computer and finishes writing an email]
[VO] Alright, now that work is in a good place, I’m ready for a break…

[00:46-00:48]: [Woman receives a push alert notification on her phone (not showing the screen); calendar reminder appears on screen]
[VO] …and my next injection of EBGLYSS.
[Caption] Time for your next injection of EBGLYSS.

[00:49-00:50]: [Woman looks back at dog]
[VO] At first I wasn’t sure how…

[00:51-00:52]: [Dog perks up from laying on couch]
[VO] …EBGLYSS would fit into my life…

[00:53-00:54]: [Woman and dog leave living room together]
[VO] …but making EBGLYSS part of my routine…
[Legal Super] FOR CAREGIVERS
If you’re a caregiver helping someone to inject, please carefully read the full Instructions for Use before injecting.

[00:55-00:56]: [Woman and dog head to the door]
[VO] …was simple.
[Legal Super] FOR CAREGIVERS
If you’re a caregiver helping someone to inject, please carefully read the full Instructions for Use before injecting.

[00:57-01:00]: [Woman attaches leash to dog’s collar]
[VO] Ok boy, you ready? Let’s go.
[Legal Super] FOR CAREGIVERS
If you’re a caregiver helping someone to inject, please carefully read the full Instructions for Use before injecting.

[01:01-01:05]: [Woman is walking dog in park]
[VO] EBGLYSS is taken once every 2 weeks until week 16 or later…

[01:06-01:08]: [Dosing schedule animates over woman and dog walking in a park; dosing schedule animates]
[VO] …with 2 injections taken at week 0 and week 2
[Legal Super] Please see the full dosing schedule and guidelines at: https://EBGLYSS.lilly.com/taking-ebglyss

[01:09-01:11]: [Dosing schedule continues animating over woman and dog walking in park; dosing schedule animates]
[VO] If you see skin improvements at 16 weeks…
[Legal Super] Please see the full dosing schedule and guidelines at: https://EBGLYSS.lilly.com/taking-ebglyss

[01:12-01:14]: [Dosing schedule animates over woman and dog walking in park; dosing schedule continues animating]
[VO] …you and your doctor can discuss switching to once-monthly dosing…
[Legal Super] Please see the full dosing schedule and guidelines at: https://EBGLYSS.lilly.com/taking-ebglyss

[01:15-01:18]: [Dosing schedule animates over woman and dog walking in park; dosing schedule continues animating]
[VO] …which is once every 4 weeks.
[Legal Super] Please see the full dosing schedule and guidelines at: https://EBGLYSS.lilly.com/taking-ebglyss

[01:19-01:23]: [Woman returns from walking the dog and hangs up the leash]
[VO] Alright, now it’s time for my EBGLYSS injection.

[01:24-01:27]: [Woman walks into the kitchen; injection steps animate on screen]
[VO] At first I was a little nervous about the injection process…

[Caption] 3 basic injection steps

Uncap the Pen
Place and Unlock
Press and Hold for 15 Seconds

[01:28-01:29]: [Woman opens the fridge where the EBGLYSS carton is on the shelf; injection steps remain on screen]
[VO]: …but after learning these 3 basic injection steps...

[Caption] 3 basic injection steps

Uncap the Pen
Place and Unlock
Press and Hold for 15 Seconds

[01:30-01:31]: [EBGLYSS carton on refrigerator shelf; injection steps remain on screen]
[VO]: …I’ve really gotten the hang of it.

[Caption] 3 basic injection steps

Uncap the Pen
Place and Unlock
Press and Hold for 15 Seconds

[01:32-01:34]: [Woman grabs EBGLYSS carton from the fridge; injection steps remain on screen]
[VO]: Before I inject, I’ll take EBGLYSS out of the fridge.

[Caption] 3 basic injection steps

Uncap the Pen
Place and Unlock
Press and Hold for 15 Seconds

[01:35-01:38]: [Woman places carton on kitchen counter; storing EBGLYSS graphic animates on screen]
[VO]: I can also keep my Pen in the original carton at room temperature…
[Caption] Storing EBGLYSS
Store EBGLYSS in your refrigerator. Keep your Pen in the original carton to protect it from light. Keep away from children. Do not freeze. Do not shake.

[01:39-01:42]: [EBGLYSS on counter; storing EBGLYSS graphic animates on screen]
[VO]: for up to 7 days, which is handy if I’m traveling.
[Caption] Storing EBGLYSS
Store EBGLYSS in your refrigerator. Keep your Pen in the original carton to protect it from light. Keep away from children. Do not freeze. Do not shake.
[Legal Super] Do not store above 86˚F (30˚C). Dispose of the EBGLYSS Pen if not used within 7 days at room temperature. Do not microwave your Pen, or run hot water over it, or leave it in direct sunlight.

[01:43-01:46]: [Woman removes EBGLYSS from the carton and inspects it; captions build with magnifying glass icon]
[VO] Before I begin, I'll inspect the medicine to make sure it’s not expired…

[01:47-01:50]: [Woman continues inspecting the EBGLYSS Pen in the background; caption builds with magnifying glass icon]
[VO] …and the liquid is clear and colorless to slightly yellow to slightly brown.
[Caption] Inspect your Pen and medicine
√ Make sure you have the right medicine.
√ The medicine inside should be clear. It may be colorless to slightly yellow to slightly brown.
X Do not use if the Pen looks damaged, if the medicine is cloudy, is discolored, or has particles, or if the expiration date printed on the label has passed.
X Do not use if medicine is frozen.

[01:51-01:52]: [Woman continues inspecting the EBGLYSS Pen; caption remains on screen]
[VO] Looks good to me.
[Caption] Inspect your Pen and medicine
√ Make sure you have the right medicine.
√ The medicine inside should be clear. It may be colorless to slightly yellow to slightly brown.
X Do not use if the Pen looks damaged, if the medicine is cloudy, is discolored, or has particles, or if the expiration date printed on the label has passed.
X Do not use if medicine is frozen.

[01:53-01:55]: [Woman washes hands; caption builds with handwashing icon]
[VO] Next, I’ll wash my hands with soap and water.
[Caption] Get ready
Wash your hands with soap and water.

[01:56-01:57]: [Woman finishes washing hands; caption builds with handwashing icon]
[VO] Now, I’ll choose my injection site.
[Caption] Get ready
Wash your hands with soap and water.

[01:58-02:01]: [Woman is choosing her injection site; caption builds with injection site icon; injection areas are highlighted on the body]
[VO] I can ask someone to help me inject in the back of my upper arm…
[Caption] Choose and clean your injection site.
Do not inject in the exact same spot every time. You can use the same area of your body but choose a different spot in that area.

[02:02-02:05]: [Woman is choosing her injection site; caption builds on screen; injection areas are highlighted on the body]
[VO] …or I can inject myself in the front of my thigh or in my belly.
[Caption] Choose and clean your injection site
Avoid areas where the skin is tender, bruised, red, hard, or in an area of skin that is affected by atopic dermatitis or other lesions.

[02:06-02:08]: [Woman is choosing her injection site; caption with injection site icon remain; injection areas are highlighted on the body]
[VO] Today, I will inject EBGLYSS in my belly.
[Caption] Choose and clean your injection site.
Avoid areas where the skin is tender, bruised, red, hard, or in area of skin that is affected by atopic dermatitis or other skin lesions.

[02:09-02:12]: [Woman cleans belly with alcohol wipe; caption builds with check mark icon]
[VO] I’ll clean the injection site with an alcohol wipe and let it dry.
[Caption] Prepare your skin
Clean your injection site with an alcohol wipe and let it dry.

[02:13-02:14]: [Woman ensures lock ring is locked; line circles the lock ring and Step 1 banner starts to build; arrow points to Needle End]
[VO] I'll make sure the Pen is locked.
[Legal Super] Needle End
The device in this video is for demonstration purposes only. The actual device will include the words Needle End near the location of the needle.

[02:15-02:19]: [Woman uncaps the Pen; caption builds with check mark icon]
[VO] Now I’ll twist off the gray base cap and throw the cap away in my trash.
[Caption] Step 1
Uncap the Pen
[Legal Super] Needle End
Do not put the gray base cap back on—this could damage the needle. Do not touch the needle inside the clear base.

[02:20-02:23]: [Woman places the Pen against her body; caption builds with check mark icon]
[VO] I'll place and hold the clear base flat and firmly against my skin.
[Caption] Step 2
Place and Unlock

[02:24-02:28]: [Woman unlocks the Pen; caption builds with check mark icon; circular line animates as the lock ring is unlocked]
[VO] With the clear base on my skin, I'll turn the lock ring to the unlock position.
[Caption] Step 2
Place and Unlock

[02:29-02:32]: [Woman hears the first click and holds the purple button for 15 seconds; caption builds with check mark icon; 15-second countdown animates]
[VO] All I need to do is press and hold the purple injection button…
[Caption] Step 3
Press and Hold for 15 Seconds

[02:33-02:36]: [Woman hears the first click and holds the purple button for 15 seconds; caption remains with check mark icon; 15-second countdown begins]
[VO] …for 15 seconds, until I hear two loud clicks.
[Caption] Step 3
Press and Hold for 15 Seconds

[02:37-02:40]: [Woman is holding the purple button for 15 seconds; caption remains with check mark icon; 15-second countdown continues]
[VO] The first click lets me know the injection has started.
[Caption] Step 3
Press and Hold for 15 Seconds

[02:41-02:42]: [Woman is holding the purple button for 15 seconds; caption remains with check mark icon; 15-second countdown continues]
[VO] It’s nice that I don’t have to see the needle.
[Caption] Step 3
Press and Hold for 15 Seconds

[02:43-02:45]: [Woman is holding the purple button for 15 seconds; caption with check mark icon fades; 15-second countdown finishes and fades; “Click” animates]
[VO] I’ll keep holding until I hear a second click…
[Caption] Step 3
Press and Hold for 15 Seconds

[02:46-02:47]: [Woman hears the 2nd click and releases the purple button; caption builds with star icon]
[VO] …which lets me know when the injection is done.
[Caption] Finish 2 clicks, 15 seconds and the injection is finished. Another way to know the injection is complete is when the gray plunger is visible.

[02:48-02:52]: [Woman hears the 2nd click and releases the purple button; “Click” animates on Pen; caption remains with star icon]
[VO] And that’s it! 2 clicks, 15 seconds, and I’m just about finished.
[Caption] Finish 2 clicks, 15 seconds and the injection is finished. Another way to know the injection is complete is when the gray plunger is visible.

[02:53-02:56]: [Woman prepares to dispose of EBGLYSS and pulls sharps disposal container from first shelf in the cabinet at eye level; caption builds with disposal icon]
[VO] After my injection, I’ll safely throw away the used Pen…
[Caption] Dispose of used Pen properly.
Put the used EBGLYSS Pen in an FDA-cleared sharps disposal container right away after use. Do not throw away Pen(s) in your household trash.

[02:57-03:00]: [Woman disposes of EBGLYSS in sharps disposal container; Lilly Support Services logo; caption updates with children and pets’ safety copy]
[VO] …in the free sharps disposal container that Lilly Support Services™ provided.
[Caption] Dispose of used Pen properly.
Keep sharps disposal container away from children and pets.
[Legal Super] Sharps disposal container is for demonstration purposes only.

[03:01-03:02]: [Woman puts sharps disposal container back in cabinet; Lilly Support Services logo; caption updates with proper sharps container disposal copy]
[Caption] Dispose of used Pen properly.
When your sharps disposal container is almost full, follow your community guidelines for the right way to throw it away. Do not recycle your used sharps disposal container.
[Legal Super] Visit www.FDA.gov/safesharpsdisposal to learn about sharps disposal in your state.

[03:03-03:07]: [Woman gives dog a treat; Lilly Support Services logo; disposal icon and caption fades]
[VO] Don’t worry boy, I didn’t forget about you!
[Caption] Dispose of used Pen properly.
When your sharps disposal container is almost full, follow your community guidelines for the right way to throw it away. Do not recycle your used sharps disposal container.
[Legal Super] Visit www.FDA.gov/safesharpsdisposal to learn about sharps disposal in your state.

[3:08-3:10]: [Woman and dog walk back over to workstation where dog lies down next to desk; Lilly Support Services logo; caption builds with headset icon]
[VO] That didn’t take long.
[Legal Super] Please carefully read the full Instructions for Use before injecting EBGLYSS.

[03:11-03:13]: [Woman pets dog; Lilly Support Services logo; caption with headset icon remain]
[VO] I’m glad that I can fit my monthly injection into my routine…
[Caption] Scan here
For additional support with virtual or over-the-phone training by a registered nurse.
[Legal Super] Please carefully read the full Instructions for Use before injecting EBGLYSS.

[03:14-03:16]: [Woman pets dog; Lilly Support Services logo; caption with headset icon fades]
[VO] …with only 3 basic injection steps.
[Caption] Scan here
For additional support with virtual or over-the-phone training by a registered nurse.
[Legal Super] Please carefully read the full Instructions for Use before injecting EBGLYSS.

[03:17-03:19]: [Woman returns to workstation]
[VO] Now, I can get back to my day.

[03:20-07:24]: [CBS scrolls]
[VO] INDICATION AND SAFETY SUMMARY
EBGLYSS is an injectable medicine used to treat adults and children 12 years of age and older who weigh at least 88 pounds (or 40 kilograms) with moderate-to-severe eczema, also called atopic dermatitis, that is not well controlled with prescription therapies used on the skin (or topical), or who cannot use topical therapies. EBGLYSS can be used with or without topical corticosteroids.

It is not known if EBGLYSS is safe and effective in children less than 12 years of age or in children 12 years to less than 18 years of age who weigh less than 88 pounds (or 40 kilograms).

WARNINGS - Do not use EBGLYSS if you are allergic to lebrikizumab-lbkz or to any of the ingredients in EBGLYSS. See the Patient Information leaflet that comes with EBGLYSS for a complete list of ingredients.

BEFORE USING
Before using EBGLYSS, tell your healthcare provider about all your medical conditions, including if you:

Have a parasitic (or helminth) infection.
Are scheduled to receive any vaccinations. You should not receive a “live vaccine” if you are treated with EBGLYSS.
Are pregnant or plan to become pregnant. It is not known if EBGLYSS will harm your unborn baby. If you become pregnant during treatment with EBGLYSS, you or your healthcare provider can call Eli Lilly and Company at 1-800-LillyRx (1-800-545-5979) to report the pregnancy.
Are breastfeeding or plan to breastfeed. It is not known if EBGLYSS passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

POSSIBLE SIDE EFFECTS
EBGLYSS can cause serious side effects, including:

Allergic reactions. EBGLYSS can cause allergic reactions that may sometimes be severe. Stop using EBGLYSS and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms:
- breathing problems or wheezing
- swelling of the face, lips, mouth, tongue or throat
- hives
- itching
- fainting, dizziness, feeling lightheaded
- skin rash
- cramps in your stomach area (or abdomen)
Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision.

The most common side effects of EBGLYSS include:

eye and eyelid inflammation, including redness, swelling, and itching
injection site reactions
shingles (herpes zoster)

These are not all of the possible side effects of EBGLYSS. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

HOW TO TAKE

See the detailed “Instructions for Use” that come with EBGLYSS for information about how to prepare and inject EBGLYSS and how to properly store and throw away (or dispose of) used EBGLYSS prefilled pens and prefilled syringes.
Use EBGLYSS exactly as prescribed by your healthcare provider.
EBGLYSS is given as an injection under the skin (or subcutaneous injection).
If your healthcare provider decides that you or a caregiver can give the injections of EBGLYSS, you or a caregiver should receive training on the right way to prepare and inject EBGLYSS. Do not try to inject EBGLYSS until you have been shown the right way by your healthcare provider. In children 12 years of age and older, EBGLYSS should be given by a caregiver.
If you miss a dose of EBGLYSS, inject the missed dose as soon as possible, then inject your next dose at your regular scheduled time.

LEARN MORE
EBGLYSS is a prescription medicine available as a 250 milligrams per 2 milliliter injection prefilled pen or prefilled syringe. For more information, call 1-800-545-5979 or go to ebglyss.lilly.com

This summary provides basic information about EBGLYSS but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking to your doctor. Be sure to talk to your doctor or other healthcare provider about EBGLYSS and how to take it. Your doctor is the best person to help you decide if EBGLYSS is right for you.

[Caption] INDICATION AND SAFETY SUMMARY
EBGLYSS^® (EHB-glihs) is an injectable medicine used to treat adults and children 12 years of age and older who weigh at least 88 pounds (40 kg) with moderate-to-severe eczema (atopic dermatitis) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. EBGLYSS can be used with or without topical corticosteroids.

It is not known if EBGLYSS is safe and effective in children less than 12 years of age or in children 12 years to less than 18 years of age who weigh less than 88 pounds (40 kg).

BEFORE USING
Before using EBGLYSS, tell your healthcare provider about all your medical conditions, including if you:

Have a parasitic (helminth) infection.
Are scheduled to receive any vaccinations. You should not receive a “live vaccine” if you are treated with EBGLYSS.
Are pregnant or plan to become pregnant. It is not known if EBGLYSS will harm your unborn baby. If you become pregnant during treatment with EBGLYSS, you or your healthcare provider can call Eli Lilly and Company at 1-800-LillyRx (1-800-545-5979) to report the pregnancy.
Are breastfeeding or plan to breastfeed. It is not known if EBGLYSS passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

POSSIBLE SIDE EFFECTS
EBGLYSS can cause serious side effects, including:

Allergic reactions. EBGLYSS can cause allergic reactions that may sometimes be severe. Stop using EBGLYSS and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms:
- breathing problems or wheezing
- swelling of the face, lips, mouth, tongue or throat
- hives
- itching
- fainting, dizziness, feeling lightheaded
- skin rash
- cramps in your stomach area (abdomen)
Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision.

The most common side effects of EBGLYSS include:

eye and eyelid inflammation, including redness, swelling, and itching
injection site reactions
shingles (herpes zoster)

These are not all of the possible side effects of EBGLYSS. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

HOW TO TAKE

See the detailed “Instructions for Use” that comes with EBGLYSS for information about how to prepare and inject EBGLYSS and how to properly store and throw away (dispose of) used EBGLYSS prefilled pens and prefilled syringes.
Use EBGLYSS exactly as prescribed by your healthcare provider.
EBGLYSS is given as an injection under the skin (subcutaneous injection).
If your healthcare provider decides that you or a caregiver can give the injections of EBGLYSS, you or a caregiver should receive training on the right way to prepare and inject EBGLYSS. Do not try to inject EBGLYSS until you have been shown the right way by your healthcare provider. In children 12 years of age and older, EBGLYSS should be given by a caregiver.
If you miss a dose of EBGLYSS, inject the missed dose as soon as possible, then inject your next dose at your regular scheduled time.

LEARN MORE
EBGLYSS is a prescription medicine available as a 250 mg/2 mL injection prefilled pen or prefilled syringe. For more information, call 1-800-545-5979 or go to ebglyss.lilly.com

LK CON BS AD APP

[Lilly logo]

EBGLYSS^®, its delivery device base, and Lilly Support Services^™ are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates. PP-LK-US-0873 08/2025 © Lilly USA, LLC 2025. All rights reserved.

[07:25-07:26]: [EBGLYSS waves animate on screen; EBGLYSS waves whoosh through frame]

[07:27-07:29]: [EBGLYSS logo animates on screen]

[00:00-00:01]: [EBGLYSS waves animate on screen; EBGLYSS waves whoosh through frame]

[00:02-00:04]: [EBGLYSS logo animates on]

[00:05-00:07]: [Woman is working on her computer]
[Legal Super] Actor portrayal.

[00:08-00:14]: [EBGLYSS logo and safety information build and remain on the screen; title card builds on screen]
[VO] This video will show you how to properly administer EBGLYSS using the Prefilled Syringe.
[Caption] Using your EBGLYSS Prefilled Syringe
[Legal Super] Please see safety information throughout this video and the Indication and Safety Summary at the end of the video.

[00:15-00:16]: [EBGLYSS logo and safety information remain on the screen; title card on screen]
[VO] Please see safety information throughout this video…
[Caption] Using your EBGLYSS Prefilled Syringe
[Legal Super] Please see safety information throughout this video and the Indication and Safety Summary at the end of the video.

[00:17-00:19]: [EBGLYSS logo and safety information remain on the screen; title card on screen]
[VO] …and the Indication and Safety Summary at the end of the video.
[Caption] Using your EBGLYSS Prefilled Syringe
[Legal Super] Please see safety information throughout this video and the Indication and Safety Summary at the end of the video.

[00:20-00:23]: [EBGLYSS logo and safety information remain on the screen; title card on screen]
[VO] It is important to read the full Instructions for Use before injecting.
[Caption] Using your EBGLYSS Prefilled Syringe
[Legal Super] Read the full Instructions for Use before injecting.

[00:24-00:29]: [EBGLYSS logo and safety information remain on the screen; injection chapters with icons build on screen; icons and corresponding copy animate on screen]
[VO] Do not use until you have been shown how to inject EBGLYSS by your healthcare provider.
[Caption]
[Checkmark icon] Get ready
[Injection icon] Inject
[Star icon] Finish
[Legal Super] Do not use until you have been shown how to inject EBGLYSS by your healthcare provider. If you are a parent or caregiver giving an injection to someone else, be sure to read and understand the full Instructions for Use before injecting.

[00:30-00:32]: [EBGLYSS logo, dosing information, and injection chapters remain on the screen; icons and corresponding copy on screen]
[VO] If you are a parent or caregiver giving an injection to someone else...
[Caption]
[Checkmark icon] Get ready
[Injection icon] Inject
[Star icon] Finish
[Legal Super] Do not use until you have been shown how to inject EBGLYSS by your healthcare provider. If you are a parent or caregiver giving an injection to someone else, be sure to read and understand the full Instructions for Use before injecting.

[00:33-00:38]: [EBGLYSS logo, dosing information, and injection chapters remain on the screen; icons and corresponding copy on screen]
[VO] …be sure to read and understand the full Instructions for Use before injecting.
[Caption]
[Checkmark icon] Get ready
[Injection icon] Inject
[Star icon] Finish
[Legal Super] Do not use until you have been shown how to inject EBGLYSS by your healthcare provider. If you are a parent or caregiver giving an injection to someone else, be sure to read and understand the full Instructions for Use before injecting.

[00:39-00:46]: [Woman is working on computer and finishes writing an email]
[VO] Alright, now that work is in a good place, I’m ready for a break…

[00:47-00:49]: [Woman receives a push alert notification on her phone (not showing the screen); calendar reminder appears on screen]
[VO] …and my next injection of EBGLYSS.
[Caption] Time for your next injection of EBGLYSS.

[00:50-00:53]: [Woman looks back at dog]
[VO] But before I go, I’ll get my next injection of EBGLYSS ready for when I’m back.

[00:54-00:57]: [Woman and dog walk through door frame into kitchen]
[VO] At first, I wasn’t sure how EBGLYSS would fit into my life…

[00:58-01:01]: [Woman opens fridge to find EBGLYSS; caption builds with fridge icon]
[VO] …but making EBGLYSS part of my routine was simple.
[Caption] Storing EBGLYSS
Store EBGLYSS in your refrigerator. Keep your Syringe in the original carton to protect it from light. Keep away from children. Do not freeze. Do not shake.
[Legal Super] The carton and syringe in this video are for demonstration purposes only. Refer to your carton and syringe label, which will look different.

[01:02-01:04]: [Woman grabs EBGLYSS carton off refrigerator shelf; caption builds with fridge icon]
[VO] Before I inject, I’ll take EBGLYSS out of the fridge…
[Caption] Storing EBGLYSS
Store EBGLYSS in your refrigerator. Keep your Syringe in the original carton to protect it from light. Keep away from children. Do not freeze. Do not shake.
[Legal Super] The carton and syringe in this video are for demonstration purposes only. Refer to your carton and syringe label, which will look different.

[01:05-01:08]: [Woman places EBGLYSS on the counter; caption builds with hourglass icon; 45-minute countdown begins]
[VO] …and place it on a flat surface so it can warm up to room temperature.
[Caption] Wait 45 minutes
With the Needle Cap on, allow the Syringe to warm up to room temperature for 45 minutes before injecting.
[Legal Super] Do not store above 86˚F (30˚C). Dispose of the EBGLYSS Syringe if not used within 7 days at room temperature. Do not microwave your syringe, run hot water over it, or leave it in direct sunlight. Do not use if medicine is frozen.

[01:09-01:12]: [Woman places EBGLYSS on the counter; caption with hourglass icon; 45-minute countdown begins]
[VO] I can also keep my Syringe in the original carton at room temperature...
[Caption] Wait 45 minutes
With the Needle Cap on, allow the Syringe to warm up to room temperature for 45 minutes before injecting.
[Legal Super] Do not store above 86˚F (30˚C). Dispose of the EBGLYSS Syringe if not used within 7 days at room temperature. Do not microwave your Syringe, run hot water over it, or leave it in direct sunlight. Do not use if medicine is frozen.

[01:13-01:14]: [Woman places EBGLYSS on the counter; caption with hourglass icon; 45-minute countdown begins]
[VO] …for up to 7 days,
[Caption] Wait 45 minutes
With the Needle Cap on, allow the Syringe to warm up to room temperature for 45 minutes before injecting.
[Legal Super] Do not store above 86˚F (30˚C). Dispose of the EBGLYSS Syringe if not used within 7 days at room temperature. Do not microwave your Syringe, run hot water over it, or leave it in direct sunlight. Do not use if medicine is frozen.

[01:15-01:16]: [Dog runs down hallway; 45-minute countdown]
[VO] …which is handy if I’m traveling.
[Legal Super] FOR CAREGIVERS
If you’re a caregiver helping someone to inject, please carefully read the full Instructions for Use before injecting.

[01:17-01:19]: [Woman gets dog ready to leave for a walk; 45-minute countdown]
[VO] Ok boy, you ready? Let’s go!
[Legal Super] FOR CAREGIVERS
If you’re a caregiver helping someone to inject, please carefully read the full Instructions for Use before injecting.

[01:20-01:23]: [Woman is walking dog in park]
[VO] EBGLYSS is taken once every 2 weeks until week 16 or later...

[01:24-01:26]: [Dosing schedule animates over woman and dog walking in a park; dosing schedule animates]
[VO] …with 2 injections taken at week 0 and week 2.
[Caption] EBGLYSS dosing schedule
[Legal Super] Please see the full dosing schedule and guidelines at: https://EBGLYSS.lilly.com/taking-ebglyss

[01:27-01:29]: [Dosing schedule continues animating over woman and dog walking in the park; dosing schedule animates]
[VO] If you see skin improvements at 16 weeks…
[Caption] EBGLYSS dosing schedule
[Legal Super] Please see the full dosing schedule and guidelines at: https://EBGLYSS.lilly.com/taking-ebglyss

[01:30-01:32]: [Dosing schedule continues animating over woman and dog walking in the park; dosing schedule continues animating]
[VO] …you and your doctor can discuss switching to once-monthly dosing…
[Caption] EBGLYSS dosing schedule
[Legal Super] Please see the full dosing schedule and guidelines at: https://EBGLYSS.lilly.com/taking-ebglyss

[01:33-01:36]: [Dosing schedule continues animating over woman and dog walking in the park; dosing schedule animates]
[VO] …which is once every 4 weeks.
[Caption] EBGLYSS dosing schedule
[Legal Super] Please see the full dosing schedule and guidelines at: https://EBGLYSS.lilly.com/taking-ebglyss

[01:37-01:40]: [Woman returns from walking the dog and hangs up the leash; 45-minute countdown comes to an end]
[VO] Alright, now it’s time for my EBGLYSS injection.

[01:41-01:44]: [Woman enters the kitchen and stands next to where EBGLYSS has been resting in the carton]
[VO] At first, I was a little nervous about the injection process…

[01:45-01:47]: [Woman inspects the EBGLYSS carton, Injection steps animate on screen]
[VO] …but after learning these 4 basic steps...
[Caption] 4 injection steps

[01:48-01:49]: [Woman continues inspecting the EBGLYSS carton; injection steps animate on screen]
[VO] …I’ve really gotten the hang of it.
[Caption] 4 basic injection steps

Remove the Needle Cap
Pinch and Insert
Push in the Plunger Rod
Release the Plunger Rod

[01:50-01:53]: [Woman continues inspecting the EBGLYSS carton; injection steps on screen]
[VO] Before I begin, I'll inspect the medicine to make sure it’s not expired…
[Caption] 4 basic injection steps

Remove the Needle Cap
Pinch and Insert
Push in the Plunger Rod
Release the Plunger Rod

[01:54-01:56]: [Woman removes EBGLYSS from the carton and inspects it; caption builds with magnifying glass icon]
[VO] …and the liquid is clear and colorless to slightly yellow to slightly brown.
[Caption] Inspect your Syringe and medicine
√ Make sure you have the right medicine.
√ The medicine inside should be clear. It may be colorless to slightly yellow to slightly brown. Some air bubbles are normal.
X Do not use if the Needle Cap is missing or not securely attached. Do not use if the Syringe looks damaged, if the medicine is cloudy, is discolored, or has particles, or if the expiration date printed on the label has passed.
[Legal Super] The carton and syringe in this video are for demonstration purposes only. Refer to your carton and syringe label, which will look different.
TIP: Do not pull back on the Plunger Rod at any time. You may gently rotate the Plunger Rod to view the Syringe label.

[01:57-01:58]: [Woman continues inspecting the EBGLYSS Syringe; caption with magnifying glass icon remains on screen]
[VO] Looks good to me.
[Caption] Inspect your Syringe and medicine
√ Make sure you have the right medicine.
√ The medicine inside should be clear. It may be colorless to slightly yellow to slightly brown. Some air bubbles are normal.
X Do not use if the Needle Cap is missing or not securely attached. Do not use if the Syringe looks damaged, if the medicine is cloudy, is discolored, or has particles, or if the expiration date printed on the label has passed.
[Legal Super] The carton and syringe in this video are for demonstration purposes only. Refer to your carton and syringe label, which will look different. TIP: Do not pull back on the Plunger Rod at any time. You may gently rotate the Plunger Rod to view the Syringe label.

[01:59-02:01]: [Woman washes hands; caption builds with hand washing icon]
[VO] Next, I’ll wash my hands with soap and water.
[Caption] Get ready
Wash your hands with soap and water.

[02:02-02:04]: [Woman finishes washing her hands; caption with hand washing icon]
[VO] Now, I’ll choose my injection site.
[Caption] Get ready
Wash your hands with soap and water.

[02:05-02:07]: [Woman is choosing injection site; caption builds with injection site icon; injection areas are highlighted on the body]
[VO] I can ask someone to help me inject in the back of my upper arm…
[Caption] Choose and clean your injection site
Do not inject in the exact same spot every time. You can use the same area of your body but choose a different spot in that area.

[02:08-02:12]: [Woman is choosing injection site; caption builds with injection site icon; injection areas are highlighted on the body]
[VO] …or I can inject myself in the front of my thigh or in my belly.
[Caption] Choose and clean your injection site
Avoid areas where the skin is tender, bruised, red, hard, or in an area of skin that is affected by atopic dermatitis or other skin lesions.

[02:13-02:15]: [Woman is choosing injection site; caption with injection site icon remains; injection areas are highlighted on the body]
[VO] Today, I will inject EBGLYSS in my belly.
[Caption] Choose and clean your injection site
Avoid areas where the skin is tender, bruised, red, hard, or in an area of skin that is affected by atopic dermatitis or other skin lesions.

[02:16-02:20]: [Woman cleans belly with alcohol wipe; caption builds with check mark icon]
[VO] I’ll clean the injection site with an alcohol wipe and let it dry.
[Caption] Prepare your skin
Clean your injection site with an alcohol wipe and let it dry.

[02:21-02:24]: [Woman uncaps the Prefilled Syringe; caption builds with check mark icon]
[VO] Now I’ll remove the Needle Cap by holding the middle of the Syringe Body…
[Caption] Step 1
Remove Needle Cap

[02:25-02:26]: [Woman uncaps the Prefilled Syringe; caption builds with check mark icon]
[VO] …and carefully pulling off the Cap.
[Caption] Step 1
Remove Needle Cap
[Legal Super] Do not dispose of the Syringe and Needle Cap in your household trash. Do not put the Needle Cap back on—this could damage the Needle. Do not touch the Needle.

[02:27-02:31]: [Woman pinches and holds a fold of skin and then inserts the Needle; caption builds with check mark icon; directional cue showing 45° angle builds over the injection site]
[VO] Next, I’ll gently pinch a fold of skin at the injection site…
[Caption] Step 2
Pinch and Insert

[02:32-02:35]: [Woman pinches and holds a fold of skin and then inserts the Needle; caption builds with check mark icon; directional cue showing the 45° angle builds over the injection site]
[VO] …and insert the Needle completely into the fold of skin at about a 45° angle.
[Caption] Step 2
Pinch and Insert

[02:36-02:40]: [Woman gently relaxes the pinch and pushes the Plunger Rod all the way down; caption with check mark icon]
[VO] Then, I’ll relax the pinch and slowly push the Plunger all the way down.
[Caption] Step 3
Push in the Plunger Rod

[02:41-02:45]: [Woman continues pushing plunger down; caption builds with check mark icon]
[VO] Sometimes I feel a bit of resistance when I’m injecting, but that’s totally normal.
[Caption] Step 3
Push in the Plunger Rod
[Legal Super] The entire dose has to be administered to activate the Needle Shield.

[02:46-02:50]: [Woman releases thumb off plunger until Needle Shield covers Needle; caption builds with check mark icon]
[VO] Now I’ll lift my thumb off the Plunger until the Needle is covered by the Needle Shield.
[Caption] Step 4
Release the Plunger Rod

[02:51-02:54]: [Woman removes syringe from body; caption builds with star icon]
[VO] And that’s it! 4 steps and I’m just about finished.
[Caption] Finish
Lightly press a cotton ball or gauze on the injection site if you see any blood. Do not rub your skin after the injection.
[Legal Super] Do not put the Needle Cap back on the Syringe.

[02:55-02:56]: [Woman pulls sharps disposal container from first shelf in the cabinet at eye level; caption builds with disposal icon]

[02:57-3:00]: [Woman prepares to dispose of EBGLYSS; caption builds with disposal icon]
[VO] After my injection, I’ll safely throw away the used Syringe…
[Caption] Dispose of used Syringe properly
Put the used EBGLYSS Syringe in an FDA-cleared sharps disposal container right away after use.
Do not throw away Syringe(s) in your household trash.

[03:01-3:05]: [Woman disposes of EBGLYSS in sharps disposal container; Lilly Support Services^™ logo; caption updates with children and pet safety copy]
[VO] ...in the free sharps disposal container that Lilly Support Services^™ provided.
[Caption] Dispose of used Syringe properly
Keep sharps disposal container away from children and pets.
[Legal Super] Sharps disposal container is for demonstration purposes only.

[03:06-3:08]: [Woman puts sharps disposal container back in cabinet, and pulls out treats for dog; Lilly Support Services^™ logo; caption updates with disposal container copy]
[Caption] Dispose of used Syringe properly
When your sharps disposal container is almost full, follow your community guidelines for the right way to throw it away. Do not recycle your used sharps disposal container.
[Legal Super] Visit www.FDA.gov/safesharpsdisposal to learn about sharps disposal in your state.

[03:09-03:11]: [Woman puts sharps disposal container back in cabinet, and pulls out treats for dog; Lilly Support Services™ logo; caption remains]
[VO] Don’t worry boy, I didn’t forget about you!
[Caption] Dispose of used Syringe properly
When your sharps disposal container is almost full, follow your community guidelines for the right way to throw it away. Do not recycle your used sharps disposal container.
[Legal Super] Visit www.FDA.gov/safesharpsdisposal to learn about sharps disposal in your state.

[03:12-3:15]: [Woman and dog walk back over to workstation where dog lies down next to desk; Lilly Support Services^™ logo; QR code and caption builds with headset icon]
[VO] That didn’t take long.
[Legal Super] Please carefully read the full Instructions for Use before injecting EBGLYSS.

[03:16-3:18]: [Woman pets dog; Lilly Support Services^™ logo; QR code and caption remain with head set icon]
[VO] I’m glad that I can fit my monthly injection into my routine…
[Caption] Scan here
For additional support with virtual or over-the-phone training by a registered nurse.
[Legal Super] Please carefully read the full Instructions for Use before injecting EBGLYSS.

[03:19-3:21]: [Woman pets dog; Lilly Support Services^™ logo; QR code and caption remain with headset icon]
[VO] …with only 4 basic steps.
[Caption] Scan here
For additional support with virtual or over-the-phone training by a registered nurse.
[Legal Super] Please carefully read the full Instructions for Use before injecting EBGLYSS.

[03:22-3:24]: [Woman returns to workstation; Lilly Support Services logo; QR code and caption remain on screen with headset icon]
[VO] Now, I can get back to my day.
[Caption] Scan here
For additional support with virtual or over-the-phone training by a registered nurse.
[Legal Super] Please carefully read the full Instructions for Use before injecting EBGLYSS.

[03:25-07:27]: [CBS scrolls; EBGLYSS logo]
[VO] INDICATION AND SAFETY SUMMARY
EBGLYSS is an injectable medicine used to treat adults and children 12 years of age and older who weigh at least 88 pounds (or 40 kilograms) with moderate-to-severe eczema, also called atopic dermatitis, that is not well controlled with prescription therapies used on the skin (or topical), or who cannot use topical therapies. EBGLYSS can be used with or without topical corticosteroids.

It is not known if EBGLYSS is safe and effective in children less than 12 years of age or in children 12 years to less than 18 years of age who weigh less than 88 pounds (or 40 kilograms).

BEFORE USING
Before using EBGLYSS, tell your healthcare provider about all your medical conditions, including if you:

Have a parasitic (or helminth) infection.
Are scheduled to receive any vaccinations. You should not receive a “live vaccine” if you are treated with EBGLYSS.
Are pregnant or plan to become pregnant. It is not known if EBGLYSS will harm your unborn baby. If you become pregnant during treatment with EBGLYSS, you or your healthcare provider can call Eli Lilly and Company at 1-800-LillyRx (1-800-545-5979) to report the pregnancy.
Are breastfeeding or plan to breastfeed. It is not known if EBGLYSS passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

POSSIBLE SIDE EFFECTS
EBGLYSS can cause serious side effects, including:

Allergic reactions. EBGLYSS can cause allergic reactions that may sometimes be severe. Stop using EBGLYSS and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms:
- breathing problems or wheezing
- swelling of the face, lips, mouth, tongue or throat
- hives
- itching
- fainting, dizziness, feeling lightheaded
- skin rash
- cramps in your stomach area (or abdomen)
Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision.

The most common side effects of EBGLYSS include:

eye and eyelid inflammation, including redness, swelling, and itching
injection site reactions
shingles (herpes zoster)

These are not all of the possible side effects of EBGLYSS. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

HOW TO TAKE

See the detailed “Instructions for Use” that come with EBGLYSS for information about how to prepare and inject EBGLYSS and how to properly store and throw away (or dispose of) used EBGLYSS prefilled pens and prefilled syringes.
Use EBGLYSS exactly as prescribed by your healthcare provider.
EBGLYSS is given as an injection under the skin (or subcutaneous injection).
If your healthcare provider decides that you or a caregiver can give the injections of EBGLYSS, you or a caregiver should receive training on the right way to prepare and inject EBGLYSS. Do not try to inject EBGLYSS until you have been shown the right way by your healthcare provider. In children 12 years of age and older, EBGLYSS should be given by a caregiver.
If you miss a dose of EBGLYSS, inject the missed dose as soon as possible, then inject your next dose at your regular scheduled time.

It is not known if EBGLYSS is safe and effective in children less than 12 years of age or in children 12 years to less than 18 years of age who weigh less than 88 pounds (40 kg).

WARNINGS–Do not use EBGLYSS if you are allergic to lebrikizumab-lbkz or to any of the ingredients in EBGLYSS. See the Patient Information leaflet that comes with EBGLYSS for a complete list of ingredients.

BEFORE USING
Before using EBGLYSS, tell your healthcare provider about all your medical conditions, including if you:

Have a parasitic (helminth) infection.
Are scheduled to receive any vaccinations. You should not receive a “live vaccine” if you are treated with EBGLYSS.
Are pregnant or plan to become pregnant. It is not known if EBGLYSS will harm your unborn baby. If you become pregnant during treatment with EBGLYSS, you or your healthcare provider can call Eli Lilly and Company at 1-800-LillyRx (1-800-545-5979) to report the pregnancy.
Are breastfeeding or plan to breastfeed. It is not known if EBGLYSS passes into your breast milk.

Tell your healthcare provider aboutall the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

POSSIBLE SIDE EFFECTS
EBGLYSS can cause serious side effects, including:

Allergic reactions. EBGLYSS can cause allergic reactions that may sometimes be severe. Stop using EBGLYSS and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms:
- breathing problems or wheezing
- swelling of the face, lips, mouth, tongue or throat
- hives
- itching
- fainting, dizziness, feeling lightheaded
- skin rash
- cramps in your stomach area (abdomen)
Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision.

The most common side effects of EBGLYSS include:

eye and eyelid inflammation, including redness, swelling, and itching
injection site reactions
shingles (herpes zoster)

These are not all of the possible side effects of EBGLYSS. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

HOW TO TAKE

See the detailed “Instructions for Use” that comes with EBGLYSS for information about how to prepare and inject EBGLYSS and how to properly store and throw away (dispose of) used EBGLYSS prefilled pens and prefilled syringes.
Use EBGLYSS exactly as prescribed by your healthcare provider.
EBGLYSS is given as an injection under the skin (subcutaneous injection).
If your healthcare provider decides that you or a caregiver can give the injections of EBGLYSS, you or a caregiver should receive training on the right way to prepare and inject EBGLYSS. Do not try to inject EBGLYSS until you have been shown the right way by your healthcare provider. In children 12 years of age and older, EBGLYSS should be given by a caregiver.
If you miss a dose of EBGLYSS, inject the missed dose as soon as possible, then inject your next dose at your regular scheduled time.

LEARN MORE
EBGLYSS is a prescription medicine available as a 250 mg/2 mL injection prefilled pen or prefilled syringe. For more information, call 1-800-545-5979 or go to ebglyss.lilly.com

LK CON BS AD APP

[Lilly logo]

EBGLYSS^®, its delivery device base, and Lilly Support Services^™ are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates. PP-LK-US-0875 08/2025 © Lilly USA, LLC 2025. All rights reserved.

[07:28-07:29]: [EBGLYSS waves animate on screen, EBGLYSS waves whoosh through frame]

[07:30-07:33]: [EBGLYSS logo animates on]

Please see Instructions for Use included with the Pen.

Please see Instructions for Use included with the Prefilled Syringe.

Two young friends hgih-fiving while another looks on

Sharing your story with EBGLYSS may help others with moderate-to-severe eczema

EBGLYSS Dosing

Discover once-monthly dosing with EBGLYSS

After 4 months of taking EBGLYSS every 2 weeks, you and your doctor can discuss switching to once-monthly dosing.*

EBGLYSS dosing schedule — The recommended dosage of EBGLYSS^® (lebrikizumab-lbkz) is an initial dose of 500 mg (two 250-mg injections) at week 0 and week 2, followed by 250 mg every 2 weeks until week 16 or later, when adequate clinical response is achieved. After initial 2-week dosing, the once-monthly dosing is 250 mg every 4 weeks.

*The recommended dosage of EBGLYSS is:

An initial dose of 500 mg (two 250-mg injections) at week 0 and week 2, followed by
250 mg every 2 weeks until week 16 or later, when adequate clinical response is achieved
Maintenance dose is 250 mg every 4 weeks

Select Important Safety Information

Do not use EBGLYSS if you are allergic to lebrikizumab-lbkz or to any of the ingredients in EBGLYSS.
See the Patient Information leaflet that comes with EBGLYSS for a complete list of ingredients.

EBGLYSS is available in both a Prefilled Pen and Prefilled Syringe

EBGLYSS gives you the flexibility to choose the device option that best suits your needs

A device designed with you in mind

In two studies, 94% of adults agreed the Pen was easy to use and were confident in their ability to use it.^†

^†Results from two studies using a similar approved Pen with the same use steps.

Image of the EBGLYSS (r-ball) (lebrikizumab-lbkz) 250 mg/2mL Prefilled Pen

The single-dose Prefilled Pen offers:

At-home administration
Hidden needle and automated injection
Up to 15 second injection time
Confirmation that you administered completely
- You’ll hear 2 clicks, one when you start the injection, and one at the end to tell you that the injection is complete
- The injection is complete when the gray plunger is visible

Image of the EBGLYSS (r-ball) (lebrikizumab-lbkz) 250 mg/2mL Prefilled Syringe

The single-dose Prefilled Syringe offers:

At-home administration
Ability to control speed of injection

Select Important Safety Information

Before using EBGLYSS, tell your healthcare provider about all your medical conditions, including if you:

Have a parasitic (helminth) infection.
Are scheduled to receive any vaccinations. You should not receive a “live vaccine” if you are treated with EBGLYSS.
Are pregnant or plan to become pregnant. It is not known if EBGLYSS will harm your unborn baby. If you become pregnant during treatment with EBGLYSS, you or your healthcare provider can call Eli Lilly and Company at 1-800-LillyRx (1-800-545-5979) to report the pregnancy.
Are breastfeeding or plan to breastfeed. It is not known if EBGLYSS passes into your breast milk.
Take prescription or over-the-counter medicines, vitamins, and herbal supplements.

How to Inject the EBGLYSS Pen

Choose and clean your injection site

Stomach area (abdomen) — at least 2 inches away from belly button (navel)
Front of thigh — at least 2 inches above the knee and 2 inches below the groin
Back of upper arm — another person should inject into the back of your upper arm

Clean the injection site with an alcohol wipe and let dry
Do not inject in the exact same spot every time. Avoid areas where the skin is tender, bruised, red, hard, or in an area of skin that is affected by atopic dermatitis or other skin lesions

Uncap the Pen

Make sure the Pen is locked
When you are ready to inject, twist off the gray base cap and throw it away in your household trash
Do not put the gray base cap back on—this could damage the needle
Do not touch the needle inside the clear base

Place and unlock

Place and hold the clear base flat and firmly against the skin
Keep the clear base on the skin, then turn the lock ring to the unlock position

Press and hold for 15 seconds

Press and hold the purple injection button and listen for 2 loud clicks:
- The first click lets you know the injection has started
- The second click lets you know the injection is complete. You will know the injection is complete when the gray plunger is visible

The injection may take up to 15 seconds

Click here for additional injection training support

Your healthcare provider should show you how to prepare and inject EBGLYSS using the Prefilled Pen. Do not inject yourself or someone else until you have been shown how to inject EBGLYSS.

These are not the complete instructions for using the Pen. Please see the Instructions for Use included with your device.

Dispose of used Pen properly

Put the used EBGLYSS Pen in an FDA-cleared sharps disposal container right away after use. Do not throw away EBGLYSS Pen(s) in your household trash. Do not recycle your used sharps disposal container. Keep sharps container away from children and pets. When your sharps container is almost full, follow your community guidelines for the right way to dispose of the sharps container.

For more information about safe sharps disposal, and for specific information about sharps disposal in the state you live in, go to the FDA website at: http://www.fda.gov/safesharpsdisposal

Please see the Instructions for Use included with the EBGLYSS device.

Learn about a Free Sharps Disposal Container

Brown haired man speaking to a doctor in an office

Possible side effects

EBGLYSS was studied in multiple clinical trials around the world

In clinical studies, side effects were experienced by some people. The most common side effects of EBGLYSS include:

Eye and eyelid inflammation, including redness, swelling, and itching
Injection site reactions
Shingles (herpes zoster)

These are not all of the possible side effects of EBGLYSS.

EBGLYSS can cause serious side effects, including:

Allergic reactions. EBGLYSS can cause allergic reactions that may sometimes be severe. Stop using EBGLYSS and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms:
- breathing problems or wheezing
- swelling of the face, lips, mouth, tongue or throat
- hives
- itching
- fainting, dizziness, feeling lightheaded
- skin rash
- cramps in your stomach area (abdomen)
Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision.

EBGLYSS is not a steroid and does not suppress your immune system

EBGLYSS:

is not an immunosuppressant or steroid
does not have boxed warnings
does not require additional lab monitoring or blood work

Additionally, in clinical trials, the safety profile of EBGLYSS through 1 year was similar to the safety profile reported through the first 16 weeks.

EBGLYSS has a safety profile that includes both children (ages 12-17 and weighing at least 88 pounds) and adults

In clinical studies, the safety profile in children was similar to that reported by all study patients.

You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.

SAFETY SUMMARY

Warnings - Do not use EBGLYSS if you are allergic to lebrikizumab-lbkz or to any of the ingredients in EBGLYSS. See the Patient Information leaflet that comes with EBGLYSS for a complete list of ingredients.

Before using
Before using EBGLYSS, tell your healthcare provider about all your medical conditions, including if you:

Have a parasitic (helminth) infection.
Are scheduled to receive any vaccinations. You should not receive a “live vaccine” if you are treated with EBGLYSS.
Are pregnant or plan to become pregnant. It is not known if EBGLYSS will harm your unborn baby. If you become pregnant during treatment with EBGLYSS, you or your healthcare provider can call Eli Lilly and Company at 1-800-LillyRx (1-800-545-5979) to report the pregnancy.
Are breastfeeding or plan to breastfeed. It is not known if EBGLYSS passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Possible side effects
EBGLYSS can cause serious side effects, including:

Allergic reactions. EBGLYSS can cause allergic reactions that may sometimes be severe. Stop using EBGLYSS and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms:
- breathing problems or wheezing
- swelling of the face, lips, mouth, tongue or throat
- hives
- itching
- fainting, dizziness, feeling lightheaded
- skin rash
- cramps in your stomach area (abdomen)
Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision.

The most common side effects of EBGLYSS include:

eye and eyelid inflammation, including redness, swelling, and itching
injection site reactions
shingles (herpes zoster)

These are not all of the possible side effects of EBGLYSS. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

How to take

See the detailed “Instructions for Use” that comes with EBGLYSS for information about how to prepare and inject EBGLYSS and how to properly store and throw away (dispose of) used EBGLYSS prefilled pens and prefilled syringes.
Use EBGLYSS exactly as prescribed by your healthcare provider.
EBGLYSS is given as an injection under the skin (subcutaneous injection).
If your healthcare provider decides that you or a caregiver can give the injections of EBGLYSS, you or a caregiver should receive training on the right way to prepare and inject EBGLYSS. Do not try to inject EBGLYSS until you have been shown the right way by your healthcare provider. In children 12 years of age and older, EBGLYSS should be given by a caregiver.
If you miss a dose of EBGLYSS, inject the missed dose as soon as possible, then inject your next dose at your regular scheduled time.

Learn more
EBGLYSS is a prescription medicine available as a 250 mg/2 mL injection prefilled pen or prefilled syringe. For more information, call 1-800-545-5979 or go to ebglyss.lilly.com

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INDICATION

EBGLYSS^® (EHB-glihs) is an injectable medicine used to treat adults and children 12 years of age and older who weigh at least 88 pounds (40 kg) with moderate-to-severe eczema (atopic dermatitis) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. EBGLYSS can be used with or without topical corticosteroids.

It is not known if EBGLYSS is safe and effective in children less than 12 years of age or in children 12 years to less than 18 years of age who weigh less than 88 pounds (40 kg).