Boy examining his abdominal area with his shirt lifted up

About Eczema

What is eczema (atopic dermatitis)?

Eczema is the most common chronic inflammatory skin condition. It can cause itchiness, dry and scaly skin, discoloration and rashes. The dry skin that comes with eczema often itches—and scratching it can cause a rash that itches even more, leading to more scratching. This “itch/scratch cycle” can cause skin to crack and bleed, which can lead to infections.

Actor portrayals.

The impact of eczema

00:01-00:04

[Video opens to an animated scene of three adults in a gym studio practicing bodyweight exercises. A blue title screen fades into frame]

Caption: Eczema: As unique as you

00:04-00:17

[The title and blue screen fade out to the same three adults, sitting together on an exercise mat in the gym studio; Woman #1 is dark complected with dark hair styled in a bun and wearing a mint-colored shirt and salmon-colored yoga pants; Woman #2 is light complected with short brown hair and wearing a faded blue shirt with navy blue yoga pants; the Man is olive complected with short brown hair and wearing a white shirt with gray shorts over black compression leggings]

Woman #1: Not again.

Woman #2: Eczema?

Woman #1: You got it. Was it that obvious?

Woman #2: Don't sweat it. Eczema, or atopic dermatitis, is the most common inflammatory skin condition and can cause the itchiness, dry and scaly skin, discoloration, and rashes like you're experiencing.

00:17-00:24

[Whiteboard on the wall, with a potted fern nearby; key eczema symptoms appear on the whiteboard]

Caption: itchiness, dry and scaly skin, discoloration, rashes

Woman #1: Tell me about it!

00:24-00:39

[Woman #1 resists scratching irritated and discolored skin on her arm twice before succumbing to her need to scratch; day turns to night, showing the chronic discomfort she experiences with her eczema symptoms; a small cyclical icon of arrows composing a circle appears]

Caption: itch-scratch cycle

Woman #1: My skin won't stop itching, but the more I scratch, the more it itches.

Woman #2: Trust me. I know that feeling all too well. That's the itch-scratch cycle. Scratching your dry, itchy skin too much could even cause cracks and bleeding, which can lead to infections.

00:39-00:54

[Frame returns to the three adults in the gym studio; Woman #1 and Woman #2 continue talking to each other]

Woman #1: How does eczema even develop?

Woman #2: The exact cause of eczema is still unknown, but there are some key factors that may contribute to its development. For one, your immune system plays a role in how your eczema develops.

Woman #1: How so?

00:54-01:03

[Whiteboard on the wall, with a potted fern nearby; shapes resembling the overproduction of protein molecules appear on a sketched diagram illustrating the three skin layers]

Caption: immune system; epidermis, dermis, subcutaneous; skin layers

Woman #2: People with eczema may have an overactive immune system that can cause the overproduction of a protein called IL-13, which can worsen eczema symptoms.

01:03-01:13

[Whiteboard on the wall, with a potted fern nearby; shapes resembling protein overproduction fade out, a photograph of a father, mother, and son fades in to where the shapes were; the male friend from earlier appears]

Caption: genetic factors

Man: There's also the possibility that eczema may have a genetic component. For example, one of my parents has eczema, so I had a greater chance of developing it myself.

01:13-01:22

[Whiteboard on the wall, with a potted fern nearby; photograph of the man’s family fades out as three small icons appear; the first icon being a factory emitting smoke; the second icon being a flower emitting allergens; the third icon being a perfume bottle emitting a fragrance]

Caption: environmental triggers

Woman #2: And there's environmental factors to eczema, too. Pollution, allergens, fragrances, and certain chemicals can all worsen symptoms.

01:22-01:35

[Frame returns to the three adults in the gym studio; the frame zooms in on the adults as they interact with each other]

Woman #1: Could the weather affect my symptoms?

Man: Yes. For example, hot weather and sweat on your skin can worsen your symptoms.

Woman #1: This is helpful information. Is there anything else I should consider?

01:35-01:58

[White screen with three arms representing the spectrum of skin tones of the three adult friends appears: one arm of dark complexion, one arm of olive complexion, and one arm of light complexion. Symptoms of eczema are present on each arm.]

Woman #2: Yes. Eczema isn't the same for everyone. Eczema may present differently depending on your skin tone. People with darker skin tones may see gray, purple, or darker brown patches on their skin, while people with lighter skin tones may have red patches.

Man: Another thing to remember is that the texture of your eczema rashes or lesions may vary depending on your skin tone.

01:58-02:12

[White screen with arms displaying eczema symptoms returns to the three adult friends in the gym studio; Woman #1 searches for resources on her mobile phone]

Woman #2: The most important thing to remember, though, is that your eczema is as unique as you are. Be kind to yourself as you embark on your eczema journey.

Woman #1: Thank you for your encouragement. I feel empowered to check out resources and learn more about my eczema.

02:12-02:19

[Music begins to fade in as Lilly logo takes foreground to conclude video]

How eczema develops

While the exact cause of eczema is still unknown, here are some key factors that may contribute to its development:

Immune system

The immune system plays a major role in eczema. People with eczema can have an overactive immune system. When your body overproduces a protein called interleukin-13, or IL-13, your eczema symptoms can worsen.

Genetics

Eczema may run in the family. For example, if your parents have eczema, you are more likely to develop it yourself.

Environmental triggers

As you may already know, pollution, allergens, fragrances, and certain chemicals can all worsen symptoms. Hot weather and sweat on your skin can also worsen eczema symptoms.

Eczema isn’t the same for everyone

In people of color, eczema can have a unique appearance

It is often hard to identify because the redness seen in lighter skin tones may appear different in darker skin. Instead, eczema may present as darker brown, purple, or ashen gray. As a result, some healthcare providers may not accurately assess the severity of your condition.

Slide 1 A patient image of the palm

Slide 2 A patient image of the back of the knee

Slide 3 A patient image of the inside elbow

Slide 4 A patient image of the hand

Slide 5 A patient image of the chest

Need help talking to your doctor about the impact of moderate-to-severe eczema?

A guide for talking with your doctor is available. Download the Doctor Discussion Guide for:

Need help finding a doctor?

Visit the National Eczema Association Provider Finder to locate a physician near you that meets your unique care needs.

Unpredictable eczema flares

Eczema isn’t just on your skin: underlying inflammation might be causing your flares to pop up with little warning. A treatment that works long term may help.

A long-term condition needs more than short-term relief

Eczema is a long-term condition, but topical treatments like creams and ointments may only offer short-term relief

For some people, keeping up with eczema treatments can be difficult. The cycle of short-term symptom relief from topical treatments may provide less relief over time, requiring you to apply more often. Some people need a treatment with long-term results.

Biologics are an advanced treatment that can work inside the body to target a specific cause of a disease. They are often used to treat diseases like moderate-to-severe eczema.

Learn how a biologic can work on moderate-to-severe eczema

Brown haired man speaking to a doctor in an office

Questions about what to expect with EBGLYSS?

SAFETY SUMMARY

Warnings - Do not use EBGLYSS if you are allergic to lebrikizumab-lbkz or to any of the ingredients in EBGLYSS. See the Patient Information leaflet that comes with EBGLYSS for a complete list of ingredients.

Before using
Before using EBGLYSS, tell your healthcare provider about all your medical conditions, including if you:

Have a parasitic (helminth) infection.
Are scheduled to receive any vaccinations. You should not receive a “live vaccine” if you are treated with EBGLYSS.
Are pregnant or plan to become pregnant. It is not known if EBGLYSS will harm your unborn baby. If you become pregnant during treatment with EBGLYSS, you or your healthcare provider can call Eli Lilly and Company at 1-800-LillyRx (1-800-545-5979) to report the pregnancy.
Are breastfeeding or plan to breastfeed. It is not known if EBGLYSS passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Possible side effects
EBGLYSS can cause serious side effects, including:

Allergic reactions. EBGLYSS can cause allergic reactions that may sometimes be severe. Stop using EBGLYSS and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms:
- breathing problems or wheezing
- swelling of the face, lips, mouth, tongue or throat
- hives
- itching
- fainting, dizziness, feeling lightheaded
- skin rash
- cramps in your stomach area (abdomen)
Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision.

The most common side effects of EBGLYSS include:

eye and eyelid inflammation, including redness, swelling, and itching
injection site reactions
shingles (herpes zoster)

These are not all of the possible side effects of EBGLYSS. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

How to take

See the detailed “Instructions for Use” that comes with EBGLYSS for information about how to prepare and inject EBGLYSS and how to properly store and throw away (dispose of) used EBGLYSS prefilled pens and prefilled syringes.
Use EBGLYSS exactly as prescribed by your healthcare provider.
EBGLYSS is given as an injection under the skin (subcutaneous injection).
If your healthcare provider decides that you or a caregiver can give the injections of EBGLYSS, you or a caregiver should receive training on the right way to prepare and inject EBGLYSS. Do not try to inject EBGLYSS until you have been shown the right way by your healthcare provider. In children 12 years of age and older, EBGLYSS should be given by a caregiver.
If you miss a dose of EBGLYSS, inject the missed dose as soon as possible, then inject your next dose at your regular scheduled time.

Learn more
EBGLYSS is a prescription medicine available as a 250 mg/2 mL injection prefilled pen or prefilled syringe. For more information, call 1-800-545-5979 or go to ebglyss.lilly.com

This summary provides basic information about EBGLYSS but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking to your doctor. Be sure to talk to your doctor or other healthcare provider about EBGLYSS and how to take it. Your doctor is the best person to help you decide if EBGLYSS is right for you.

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INDICATION

EBGLYSS^™ (EHB-glihs) is an injectable medicine used to treat adults and children 12 years of age and older who weigh at least 88 pounds (40 kg) with moderate-to-severe eczema (atopic dermatitis) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. EBGLYSS can be used with or without topical corticosteroids.

It is not known if EBGLYSS is safe and effective in children less than 12 years of age or in children 12 years to less than 18 years of age who weigh less than 88 pounds (40 kg).